AmnioWrap2

AmnioWrap2® allografts are Intended for Homologous use as a Protective Covering


AmnioWrap2®  is a placental-based allografts comprised of unseparated amnion and chorion membranes including the intact intermediate layer. The allografts are made from amniotic tissue that contain collagen extracellular matrix and a wide array of regulatory proteins including growth factors, cytokines, and chemokines.

AmnioWrap2  allografts act as a protective covering when placed over the wound bed or surgical site, providing the key components found in human placental tissues including an intact extracellular matrix (ECM), growth factors and cytokines.

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AmnioWrap2 Layers
About AmnioWrap2

AmnioWrap2 Assortment:

Ideal for acute and chronic wound application.
(Tri-Layer — 250 microns thick)
​
HCPC code: Q4221

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AmnioWrap2® is intended for homologous use as a covering and barrier for human tissue. Refer to Instructions for Use for information on safety, usage, and storage.

References

  1. AmnioWrap2® Instructions for Use
  2. Data on File
  3. Tenehaus M. The Use of Dehydrated Human Amnion/Chorion Membranes in the Treatment of Burns and Complex Wounds. Ann Plast Surg. 2017;78: S11–S13.
  4. Silini AR, Cargnoni A, Magatti M, Pianta S and Parolini O (2015) The long path of human placenta, and its derivatives, in regenerative medicine. Front. Bioeng Biotechnol.
    2015;3:162.
  5. Ramuta TZ, Šket T, Erjavec MS, Kreft ME. Antimicrobial Activity of Human Fetal Membranes: From Biological Function to Clinical Use. Front Bioeng Biotechnol. 2021;9:691522.
  6. Heckmann N, Auran R, Mirzayan R. Application of Amniotic Tissue in Orthopedic Surgery. Am J Orthoped. 2016;45(7):E421-E425.
  7. Niknejad H, Peirovi H, Jorjani M et al. Properties of the amniotic membrane for potential use in tissue engineering. Eur. Cells Mater. 2008;15(15):88-99.
  8. Moore MC, Bonvallet PP, Damaraju SM, et al. Biological characterization of dehydrated amniotic membrane allograft: Mechanisms of action and implications for wound care. J
    Biomed Mater Res. 2020;1–8.
  9. Wassmer C-H. Berishvili E. Immunomodulatory Properties of Amniotic Membrane Derivatives and Their Potential in Regenerative Medicine. Curr. Diab. Rep. 2020;20(31).
  10. Chatterjee P, Chiasson VL, Bounds KR, Mitchell BM. Regulation of the anti-inflammatory cytokines interleukin-4 and interleukin-10 during pregnancy. Front Immunol. 2014;5(23).
  11. Moreno SE, Massee M, Koob TJ. Dehydrated Human Amniotic Membrane Inhibits Myofibroblast Contraction through the Regulation of the TGFb‒SMAD Pathway In Vitro. JID
    Innov. 2021;1:100020

VENDAJE®, VENDAJE AC®, VENDAJE OPTIC® and AmnioWrap2® are perinatal tissue-derived allografts. Each product is designated as a Human Cell, Tissue, and Cellular and Tissue-Based Product (HCT/P) by the U.S. Food and Drug Administration (FDA), minimally manipulated, and produced in accordance with the FDA regulations for Good Tissue Practices (21 CFR 1270, 1271) in our AATB® accredited lab.