The Science Behind VENDAJE® and VENDAJE AC®: Superior Allograft Processing for Wound Care

At BioStem, we believe that the key to effective wound care lies in the meticulous preservation of natural tissue integrity. Our proprietary BioREtain® method for processing placental tissue, used in our VENDAJE® and VENDAJE AC ® allografts, is a testament to this belief. But what makes our process stand out, and how does it translate to better wound care outcomes for patients? Let us delve into the science behind allografts and the critical role of preserving natural tissue. The Importance of Preserving Natural Tissue

The efficacy of an allograft heavily depends on how well the natural structure of the tissue is preserved during processing. Conventional processing methods can be harsh, often involving chemical agents or high temperatures that can degrade these critical elements, reducing the graft’s effectiveness.

Our BioREtain method stands apart by adhering to a stringent 6-step process designed to maintain the natural integrity of amniotic tissue. This process can lead to:

• Enhanced Growth Factor Retention: By avoiding harsh processing techniques, we ensure that the natural growth factors within the tissue are retained.
• Improved Structural Integrity: Maintaining the natural extracellular matrix of the tissue provides a more conducive environment for wound treatment.

The BioREtain Method: Quality Without Compromise

Our commitment to quality and efficacy drives us to go the extra mile with our BioREtain method. Here is a brief overview of our process:

1. Minimally Damaging Disinfection – The membrane is submerged in an effective disinfection to eliminate pathogens.
2. Manual Hematopoietic Reduction – Blood and blood producing components are removed by hand without scraping or scrubbing to preserve the membrane structure
3. Cold Isotonic Cleansing – A series of washes in clean, low-temperature, pH-balanced solution with gentle stirring removes remaining debris while minimizing tissue and growth factor breakdown
4. Gentle & Gradual Dehydration – Slow drying of the membrane using physiological temperature preserves tissue structure and natural growth factors, preventing damage from freezing or high temperatures.
5. Precise Cutting Die Placement – Precise, manual placement of cutting dies helps ensure optimal tissue quality for each individual allograft
6. Low-Dose E-Beam Terminal Sterilization – Grafts are individually packed and terminally sterilized to an assurance level of 10 ^-6 via electron beam, avoiding harmful byproducts or excessive irradiation associated with other methods.

Results That Matter: Efficiency and Reduced Treatment Days

The superior preservation of growth factors and structural integrity allografts translates to tangible benefits:

• Accelerated Results: 27% fewer applications *
• Fewer Treatment Days: 14% fewer treatment days *

At BioStem, our dedication to excellence ensures that every VENDAJE and VENDAE AC allograft delivers the best possible outcomes. We believe that by preserving the natural integrity of amniotic tissue, we can provide a product that not only meets but exceeds the highest standards of wound care.

*https://biostemtechnologies.com/wp-content/uploads/2024/07/134280_BioStm-Pstr-L-AC-vs-BR-AC-1.jpg

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